Publications

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2025

  • Palacios, P. M.; Li, X.; Rifayee, S. B. J. S.; Tang, H.; Karabencheva-Christova, T.; Christov, C. Z.; Chang, W.-C.; Guo, Y. Regio- and Stereo-Selective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides. J. Am. Chem. Soc. 2025, 147, 52, 48166–48179. https://doi.org/10.1021/jacs.5c16374.
  • Cherilakkudy, F. H.; Thomas, M. G.; Varghese, A.; Waheed, S. O.; Krishnan, A.; Venditti, V.; Schofield, C. J.; Li, D.; Christov, C. Z.; Karabencheva-Christova, T. G. Revealing the Catalytic Mechanism of the Fe(II)/2-Oxoglutarate-Dependent Human Epigenetic Modifying Enzyme ALKBH5. Cell Rep. Phys. Sci. 2025, 6 (8), 102779. https://doi.org/10.1016/j.xcrp.2025.102779.
  • Melayikandy, S.; Krishnan, A.; Varghese, A.; Jaber Sathik Rifayee, S. B.; Waheed, S. O.; Ramanan, R.; Li, D.; Christov, C. Z.; Karabencheva-Christova, T. G. Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts. Inorg. Chem. 2025, 64 (30), 15650–15666. https://doi.org/10.1021/acs.inorgchem.5c02176.
  • Chatterjee, S.; Rankin, J. A.; Farrugia, M. A.; Rifayee, S. B. J. S.; Christov, C. Z.; Hu, J.; Hausinger, R. P. Biochemical, Structural, and Conformational Characterization of a Fungal Ethylene-Forming Enzyme. Biochemistry 2025, 64 (9), 2054–2067. https://doi.org/10.1021/acs.biochem.5c00038.
  • Jaber Sathik Rifayee, S. B.; Thomas, M. G.; Christov, C. Z. Revealing the nature of the second branch point in the catalytic mechanism of the Fe(ii)/2OG-dependent ethylene forming enzyme RSC Chem. Sci., 2025,16, 7667-7684. https://doi.org/10.1039/D4SC08378D.

2024

  • Thomas, M. G.; Jaber Sathik Rifayee, S. B.; Christov, C. Z. How Do Variants of Residues in the First Coordination Sphere, Second Coordination Sphere, and Remote Areas Influence the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate Dependent Ethylene-Forming Enzyme? ACS Catal. 2024, 14, 24, 18550–18569. https://doi.org/10.1021/acscatal.4c04010.
  • Chatterjee, S.; Fellner, M.; Rankin, JoelA.; Thomas, M. G.; J S Rifayee, S. B.; Christov, C. Z.; Hu, J.; Hausinger, R. P. Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme. Biochemistry 2024, 63 (8), 1038–1050. https://doi.org/10.1021/acs.biochem.4c00031.
  • Devadas, S.; Thomas, M. G.; Rifayee, S. B. J. S.; Varada, B.; White, W.; Sommer, E.; Campbell, K.; Schofield, C. J.; Christov, C. Origins of Catalysis in Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Histone Lysine Demethylase KDM4A with Differently Methylated Histone H3 Peptides. Chem. – Eur. J. 2024, e202403989. https://doi.org/10.1002/chem.202403989.
  • Thomas, M. G.; Jaber Sathik Rifayee, S. B.; Chaturvedi, S. S.; Gorantla, K. R.; White, W.; Wildey, J.; Schofield, C. J.; Christov, C. Z. The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorg. Chem.2024, 63 (23), 10737–10755. https://doi.org/10.1021/acs.inorgchem.4c01365.

2023

  • Rifayee, S. B. J. S.; Chaturvedi, S. S.; Warner, C.; Wildey, J.; White, W.; Thompson, M.; Schofield, C. J.; Christov, C. Z. Catalysis by KDM6 Histone Demethylases – A Synergy between the Non-Heme Iron(II) Center, Second Coordination Sphere, and Long-Range Interactions. Chemistry – A European Journal, 2023. https://doi.org/10.1002/chem.202301305.
  • Chaturvedi, S. S.; Rifayee, S. B. J. S.; Ramanan, R.; Rankin, J. A.; Hu, J.; Hausinger, R. P.; Christov, C. Can an External Electric Field Switch between Ethylene Formation and L-Arginine Hydroxylation in the Ethylene Forming Enzyme? Phys. Chem. Chem. Phys. 2023. https://doi.org/10.1039/D3CP01899G.
  • Hausinger, R. P.; Rifayee, S. B. J. S.; Thomas, M. G.; Chatterjee, S.; Hu, J.; Christov, C. Z. Biological Formation of Ethylene. RSC Chem. Biol. 2023, 4 (9), 635–646. https://doi.org/10.1039/D3CB00066D.
  • Chaturvedi, S. S.; Thomas, M. G.; Rifayee, S. B. J. S.; White, W.; Wildey, J.; Warner, C.; Schofield, C. J.; Hu, J.; Hausinger, R. P.; Karabencheva‐Christova, T. G.; Christov, C. Z. Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe II and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme. Chemistry A European J 2023. https://doi.org/10.1002/chem.202300138.

2022

  • Sosa Alfaro, V.; Waheed, S. O.; Palomino, H.; Knorrscheidt, A.; Weissenborn, M.; Christov, C. Z.; Lehnert, N. YfeX – A New Platform for Carbene Transferase Development with High Intrinsic Reactivity. Chemistry 2022, 28 (65), e202201474. https://doi.org/10.1002/chem.202201474.
  • Chaturvedi, S. S.; Jaber Sathik Rifayee, S. B.; Waheed, S. O.; Wildey, J.; Warner, C.; Schofield, C. J.; Karabencheva-Christova, T. G.; Christov, C. Z. Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe(II)-Dependent Histone Demethylase? JACS Au 2022, 2 (9), 2169–2186. https://doi.org/10.1021/jacsau.2c00345.
  • Waheed SO, Varghese A, Chaturvedi SS, Karabencheva-Christova TG, Christov CZ. How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA. ACS Catal. 2022 April 19;12:5327-5344. doi: 10.1021/acscatal.2c00024.

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