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Welcome to the computational research lab of Dr. Christo Z. Christov!
![](https://chem.sites.mtu.edu/christov/wp-content/uploads/2023/01/Christo-web-1024x768.jpeg)
We apply Combined Quantum Mechanical and Molecular Mechanical (QM/MM) and Molecular Dynamics Methods to investigate the Catalytic Mechanisms of None-Heme Fe(II)- and 2-Oxoglutarate (2OG)-Dependent Enzymes such as:
i) Histone Lysine Demethylases
ii) Ethylene-Forming Enzyme
iii) DNA Demethylases and Hydroxylases