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Marina Tanasova

Professor, Chemistry

Overview of Research in the Marina Tanasova Lab

Our research group focuses on Organic Synthesis and Chemical biology. We develop synthetic methodologies to advance synthetic approaches to highly functionalized heterocycles. Using new and existing synthetic approaches, we design and synthesize sugar-like molecular probes to specifically target cancer-relevant facilitative sugar transporters – GLUTs. We advance our research towards practical applications by developing biochemical assays and advance scientific knowledge by understanding links between impaired biological mechanisms and cancer.

  • Development of GLUT-specific molecular probes
  • Evaluating therapeutic potential of fructose transport targeting for cancer therapy and prevention.
  • Development of fructose metabolism inhibitors.
  • Development of carbohydrate transport specific drug delivery platforms
  • Development of fluorescent assays for evaluating carbohydrate transport activity and screening carbohydrate transport and metabolism inhibitors
  • Synthesis and evaluation of bioreductively-activated pharmacophores
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