{"id":126,"date":"2020-06-01T22:49:00","date_gmt":"2020-06-01T22:49:00","guid":{"rendered":"http:\/\/localhost:8888\/tiwarilab\/?p=126"},"modified":"2024-02-25T22:51:07","modified_gmt":"2024-02-25T22:51:07","slug":"protein-shapes-matter-in-alzheimers-research","status":"publish","type":"post","link":"https:\/\/chem.sites.mtu.edu\/tiwari\/protein-shapes-matter-in-alzheimers-research\/","title":{"rendered":"Protein Shapes Matter in Alzheimer\u2019s Research"},"content":{"rendered":"\n<p>Ashutosh Tiwari, associate professor of\u00a0<a href=\"https:\/\/www.mtu.edu\/chemistry\/\">chemistry<\/a>\u00a0at Michigan Tech, explains that misfolded amyloid beta proteins tend to pile up and form aggregates, which can form stringy fibrils or balled-up amorphous shapes. To understand what causes the different shapes and to assess their toxicity, Tiwari\u2019s team looked at acetylation.<\/p>\n\n\n\n<p>To learn more see article on\u00a0<a href=\"https:\/\/www.mtu.edu\/news\/stories\/2020\/may\/protein-shapes-matter-in-alzheimers-research.html\">Michigan Tech News<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1-1024x512.jpg\" alt=\"\" class=\"wp-image-128\" srcset=\"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1-1024x512.jpg 1024w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1-300x150.jpg 300w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1-768x384.jpg 768w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1-1536x768.jpg 1536w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Abeta_Figure_TOC-2048x1024-1.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Ashutosh Tiwari, associate professor of\u00a0chemistry\u00a0at Michigan Tech, explains that misfolded amyloid beta proteins tend to pile up and form aggregates, which can form stringy fibrils or balled-up amorphous shapes. To understand what causes the different shapes and to assess their toxicity, Tiwari\u2019s team looked at acetylation. To learn more see article on\u00a0Michigan Tech News<\/p>\n","protected":false},"author":1,"featured_media":127,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[4],"tags":[],"class_list":["post-126","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-michigan-tech-news"],"_links":{"self":[{"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/posts\/126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/comments?post=126"}],"version-history":[{"count":1,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/posts\/126\/revisions"}],"predecessor-version":[{"id":129,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/posts\/126\/revisions\/129"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/media\/127"}],"wp:attachment":[{"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/media?parent=126"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/categories?post=126"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-json\/wp\/v2\/tags?post=126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}