{"id":12,"date":"2024-02-24T21:19:14","date_gmt":"2024-02-24T21:19:14","guid":{"rendered":"http:\/\/localhost:8888\/tiwarilab\/?page_id=12"},"modified":"2024-05-23T12:12:01","modified_gmt":"2024-05-23T12:12:01","slug":"home","status":"publish","type":"page","link":"https:\/\/chem.sites.mtu.edu\/tiwari\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12\" class=\"elementor elementor-12\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dc9a320 e-flex e-con-boxed e-con e-parent\" data-id=\"dc9a320\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-557b03a elementor-widget elementor-widget-heading\" data-id=\"557b03a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">WELCOME TO TIWARI RESEARCH GROUP<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0dd1617 elementor-widget elementor-widget-heading\" data-id=\"0dd1617\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">RESEARCH FOCUS: PROTEIN MISFOLDING &amp; AGGREGATION DISEASES<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d812ce5 e-flex e-con-boxed e-con e-parent\" data-id=\"d812ce5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-42a5e52 elementor-widget elementor-widget-image\" data-id=\"42a5e52\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"615\" src=\"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Res-summary-1024x615-1.png\" class=\"attachment-full size-full wp-image-105\" alt=\"\" srcset=\"https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Res-summary-1024x615-1.png 1024w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Res-summary-1024x615-1-300x180.png 300w, https:\/\/chem.sites.mtu.edu\/tiwari\/wp-content\/uploads\/2024\/02\/Res-summary-1024x615-1-768x461.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fc99f61 e-flex e-con-boxed e-con e-parent\" data-id=\"fc99f61\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59c3cc1 elementor-widget elementor-widget-heading\" data-id=\"59c3cc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Overview of Research in the Tiwari Lab<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ec7921 elementor-widget elementor-widget-text-editor\" data-id=\"1ec7921\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The long-term research goal of Tiwari lab is to understand consequences of protein misfolding and aggregation in vitro and how it relates to misfolding and aggregation in vivo, and its implication for neurodegenerative diseases (e.g. Amyotrophic Lateral Sclerosis, Alzheimer\u2019s and Parkinson\u2019s disease). While all these neurodegenerative diseases share a common feature of observed aggregated proteins at the end stage of disease; the underlying mechanism(s) by which these aggregated proteins impair cellular function or cause toxicity is not clearly understood.\u00a0 To better understand the link between distinctly aggregated protein structures and their associated cellular toxicity, Tiwari lab uses diverse biochemical, biophysical, molecular biology, and cell biology techniques to:<\/p><ol><li>Identify experimental conditions that can generate diverse aggregated protein structures from the same proteins.<\/li><li>Develop novel tools and techniques to differentiate amongst the varied aggregated species of proteins.<\/li><li>Understand the relationship between aggregated protein species and its associated cellular toxicity.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8952b7e e-flex e-con-boxed e-con e-parent\" data-id=\"8952b7e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6b76a25 e-con-full e-flex e-con e-child\" data-id=\"6b76a25\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-846e337 elementor-widget elementor-widget-heading\" data-id=\"846e337\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">For More Updated List of Tiwari Lab Publications Visit<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43d432b e-con-full e-flex e-con e-child\" data-id=\"43d432b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6cf388 e-con-full e-flex e-con e-child\" data-id=\"c6cf388\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e9fe33a elementor-widget elementor-widget-button\" data-id=\"e9fe33a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/scholar.google.com\/citations?hl=en&#038;user=A01F1tIAAAAJ&#038;view_op=list_works&#038;sortby=pubdate\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">GOOGLE SCHOLAR<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-653d309 e-con-full e-flex e-con e-child\" data-id=\"653d309\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a1b38b8 elementor-widget elementor-widget-button\" data-id=\"a1b38b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.webofscience.com\/wos\/author\/record\/913558\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Web of Science ResearcherID<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f246024 e-con-full e-flex e-con e-child\" data-id=\"f246024\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-042e43f elementor-widget elementor-widget-button\" data-id=\"042e43f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/orcid.org\/0000-0001-7373-349X\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ORCID iD<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>WELCOME TO TIWARI RESEARCH GROUP RESEARCH FOCUS: PROTEIN MISFOLDING &#038; AGGREGATION DISEASES Overview of Research in the Tiwari Lab The long-term research goal of Tiwari lab is to understand consequences of protein misfolding and aggregation in vitro and how it relates to misfolding and aggregation in vivo, and its implication for neurodegenerative diseases (e.g. Amyotrophic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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