{"id":120,"date":"2020-08-14T18:14:54","date_gmt":"2020-08-14T18:14:54","guid":{"rendered":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/?page_id=120"},"modified":"2026-01-14T12:07:56","modified_gmt":"2026-01-14T16:07:56","slug":"publications","status":"publish","type":"page","link":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"120\" class=\"elementor elementor-120\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1c511354 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1c511354\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-73364d18\" data-id=\"73364d18\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5775a74c elementor-widget elementor-widget-text-editor\" data-id=\"5775a74c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>\u00a0<\/h6>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:group --><\/p>\n<div>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-style: normal; font-weight: bold;\">\n<h6><span style=\"color: #666699;\"><strong>2025<\/strong><\/span><\/h6>\n<\/li>\n<li>\n<h6 style=\"text-align: left;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c16374\"><strong data-start=\"86\" data-end=\"203\">Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides<\/strong><\/a>, Philip M. Palacios, Xiaoyun Li, Simahudeen Bathir Jaber Sathik Rifayee, Haoyu Tang, Tatyana Karabencheva-Christova, Christo Christov, Wei-chen Chang and Yisong Guo, <strong>Journal of the American Chemical Society.<\/strong><\/h6>\n<\/li>\n<li>\n<h6 style=\"text-align: left;\"><a href=\"https:\/\/doi.org\/10.1016\/j.xcrp.2025.102779\"><strong data-start=\"86\" data-end=\"203\">Revealing the catalytic mechanism of the Fe(II)\/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5<\/strong><\/a>, Fathima Hameed Cherilakkudy, Midhun George Thomas, Ann Varghese, Sodiq O. Waheed, Anandhu Krishnan, Vincenzo Venditti, Christopher J. Schofield, Deyu Li, Christo Z. Christov, Tatyana G. Karabencheva-Christova, <strong>Cell Reports Physical Science.<\/strong><\/h6>\n<\/li>\n<li>\n<h6 style=\"text-align: left;\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.inorgchem.5c02176\"><strong data-start=\"81\" data-end=\"238\">Catalytic Mechanism of the Bacterial Non-Heme Fe(II) and 2-Oxoglutarate Dependent Enzyme AlkB with Single-Stranded DNA Containing Complex Guanine Adducts<\/strong><\/a>, Sreerag Melayikandy, Anandhu Krishnan, Ann Varghese, Simahudeen Bathir Jaber Sathik Rifayee, Sodiq O. Waheed, Rajeev Ramanan, Deyu Li, Christo Z. Christov, Tatyana G. Karabencheva-Christova, <strong>Inorganic Chemistry.<\/strong><\/h6>\n<\/li>\n<li>\n<h6><span style=\"color: #666699;\"><strong>2024<\/strong><\/span><\/h6>\n<\/li>\n<li>\n<h6 style=\"text-align: left;\"><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cphc.202400303\" target=\"_blank\" rel=\"noopener\"><strong>Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non-Heme Fe(II)\/2-Oxoglutarate-Dependent Aspartyl Hydroxylase AspH, <\/strong><\/a> Anandhu Krishnan, Sodiq O. Waheed, Sreerag Melayikandy, Ciara LaRouche, Meredith Paik, Christopher J. Schofield, Tatyana G. Karabencheva-Christova, <strong>ChemPhysChem.<\/strong><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-medium wp-image-1824 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-226x300.jpg\" alt=\"\" width=\"226\" height=\"300\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-226x300.jpg 226w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-770x1024.jpg 770w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-768x1021.jpg 768w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-1155x1536.jpg 1155w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-1540x2048.jpg 1540w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/08\/bichaw.2024.63.issue-15.xlargecover-2-scaled.jpg 1925w\" sizes=\"(max-width: 226px) 100vw, 226px\" \/><\/h6>\n<\/li>\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1021\/acs.biochem.4c00076\" target=\"_blank\" rel=\"noopener\"><strong>Novel Insights into the Catalytic Mechanism of Collagenolysis by Zn(II)-Dependent Matrix Metalloproteinase-1, <\/strong><\/a>Koteswara Rao Gorantla, Anandhu Krishnan, Sodiq O. Waheed, Ann Varghese, Isabella DiCastri, Ciara LaRouche, Meredith Paik, Gregg B. Fields, and Tatyana G. Karabencheva-Christova<strong style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">, Biochemistry.<\/strong><\/h6>\n<\/li>\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1039\/D3SC05974J\" target=\"_blank\" rel=\"noopener\"><strong>Unusual catalytic strategy by non-heme Fe(ii)\/2-oxoglutarate-dependent aspartyl hydroxylase AspH, <\/strong><\/a>Anandhu krishnan, <span style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Sodiq O. Waheed,<\/span> <span style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J. Schofield,\u00a0<\/span><span style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Tatyana G. Karabencheva-Christova<\/span><strong style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">, Chemical Science.<\/strong><b><\/b><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><span style=\"color: #666699;\"><strong>2023<\/strong><\/span><\/h6>\n<\/li>\n<li style=\"font-style: normal; font-weight: bold;\">\n<h6><a href=\"https:\/\/doi.org\/10.1021\/acs.jpcb.3c04293\" target=\"_blank\" rel=\"noopener\"><strong>Catalytic Mechanism of Collagen Hydrolysis by Zinc(II)-Dependent Matrix Metalloproteinase-1<\/strong><\/a>, <span style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">Ann Varghese, Sodiq O. Waheed, Koteswararao Gorantla, Isabella DiCastri, Ciara LaRouche, Brendan Kaski, Gregg B. Fields, Tatyana G. Karabencheva-Christova, <strong>J.Phys. Chem. B. <\/strong>2023 (Cover profile).<\/span><\/h6>\n<\/li>\n<li>\n<h6><img decoding=\"async\" class=\"alignnone size-medium wp-image-1801 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2024\/03\/SC015010_OBC_PUBLICITY-1-1-229x300.png\" alt=\"\" width=\"229\" height=\"300\" \/><a style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\" href=\"https:\/\/www.cell.com\/chem-catalysis\/pdf\/S2667-1093(23)00278-6.pdf\"><strong>Revealing the catalytic strategy of FTO<\/strong><\/a><span style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight );\">, Ann Varghese, Sodiq O. Waheed, Shobhit S. Chaturvedi, Isabella DiCastri, Ciara LaRouche, Brendan Kaski, Nicolai Lehnert, Deyu Li, Christo Z. Christov, Tatyana G. Karabencheva-Christova<\/span><strong style=\"background-color: transparent; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\">, <span style=\"color: #808080;\">Chem Catalysis.<\/span><\/strong><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<div>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full\/10.1002\/chem.202300138\"><strong>Dioxygen Binding Is Controlled by the Protein Environment in Non-heme Fe<sup>II<\/sup>\u00a0and 2-Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene-Forming Enzyme<\/strong><\/a>, Dr. Shobhit S. Chaturvedi, Midhun George Thomas, Simahudeen Bathir Jaber Sathik Rifayee, Walter White, Cait Warner, Christopher J. Schofield, Jian Hu, Robert P. Hausinger, Tatyana G. Karabencheva-Christova, Christo Z. Christov<strong>, Chemistry-A European Journal<\/strong>.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><strong><a href=\"https:\/\/www.mdpi.com\/2673-8856\/3\/2\/5\">Kinetic Studies on the 2-Oxoglutarate\/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families<\/a>, <\/strong>Zhiyuan Peng, Jian Ma, Christo Z. Christov, Tatyana Karabencheva-Christova, Nicolai Lehnert and Deyu Li, <strong>DNA<\/strong>, 3, 65-84.<img decoding=\"async\" class=\"alignnone size-medium wp-image-1707 alignright\" style=\"float: right; margin: 0 0 -20px 12px 18px;\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-226x300.jpg\" alt=\"\" width=\"226\" height=\"300\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-226x300.jpg 226w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-770x1024.jpg 770w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-768x1021.jpg 768w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-1155x1536.jpg 1155w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-1540x2048.jpg 1540w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/12\/COVER-Journal-of-physiclachemB-2023-scaled.jpg 1925w\" sizes=\"(max-width: 226px) 100vw, 226px\" \/><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full\/10.1002\/cphc.202200649\"><strong>Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase-1<\/strong><\/a>, Sodiq O. Waheed, Ann Varghese, Isabella DiCastri, Brendan Kaski, Ciara LaRouche, Gregg B. Fields, Tatyana G. Karabencheva-Christova, <strong>ChemPhysChem<\/strong>, 2023 (Cover profile)\u00a0<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><span style=\"color: #666699;\"><strong>2022<\/strong><\/span><\/h6>\n<\/li>\n<li>\n<h6><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/jacsau.2c00345\"><strong>Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe (II)-Dependent Histone Demethylase?<\/strong><\/a>, Shobhit S. Chaturvedi, Simahudeen Bathir Jaber Sathik Rifayee, Sodiq O. Waheed, Jon Wildey, Cait Warner, Christopher J. Schofield, Tatyana G. Karabencheva-Christova Christo Z. Christov, <strong>JACS Au<\/strong>, 2, 2169\u20132186.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h6><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acscatal.2c00024\"><strong>How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA<\/strong><\/a>, Sodiq O. Waheed, Ann Varghese, Shobhit S. Chaturvedi, Tatyana G. Karabencheva-Christova and Christo Z. Christov, <strong>ACS Catalysis<\/strong>, 12, 5327\u20135344.<\/h6>\n<\/li>\n<li>\n<h6><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1033 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-226x300.jpg\" alt=\"\" width=\"226\" height=\"300\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-226x300.jpg 226w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-772x1024.jpg 772w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-768x1018.jpg 768w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-1158x1536.jpg 1158w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy-204x270.jpg 204w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2023\/07\/Sodiq-chemphy.jpg 1251w\" sizes=\"(max-width: 226px) 100vw, 226px\" \/><strong><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/cphc.202100680\" data-type=\"URL\" data-id=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/cphc.202100680\">Effects of the Nature of Metal Ion, Protein and Substrate on the Catalytic Center in Matrix Metalloproteinase-1: Insights from Multilevel MD, QM\/MM and QM Studies<\/a><\/strong>, Ann Varghese, Shobhit S. Chaturvedi, Bella DiCastri, Emerald Mehler, Gregg B. Fields, Tatyana G. Karabencheva-Christova, <strong>ChemPhysChem<\/strong>, 2022 (Cover profile)<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<div>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}},\"textColor\":\"black\"} --><\/p>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2021<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- wp:list-item --><\/p>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1007\/s00775-021-01876-6\"><strong>A synergy between the catalytic and structural Zn(II) ions and the enzyme and substrate dynamics underlies the structure\u2013function relationships of matrix metalloproteinase collagenolysis,<\/strong><\/a> Ann Varghese, Shobhit S. Chaturvedi, Gregg B. Fields, Tatyana G. Karabencheva-Christova, <strong>Journal of Biological Inorganic Chemistry<\/strong>,23,583-597.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/doi.org\/10.1021\/acscatal.0c05034\">Catalytic Mechanism of Human Ten-Eleven Translocation-2 (TET2) Enzyme: Effects of Conformational Changes, Electric Field, and Mutations<\/a>,<\/strong> Sodiq O. Waheed, Shobhit S. Chaturvedi, Tatyana G. Karabencheva-Christova, Christo Z. Christov, <strong>ACS Catalysis<\/strong>, 11, 3877-3890<img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-937 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-226x300.png\" alt=\"\" width=\"226\" height=\"300\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-226x300.png 226w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-772x1024.png 772w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-768x1019.png 768w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-1158x1536.png 1158w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-1544x2048.png 1544w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1-204x270.png 204w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2022\/03\/cover-image-1.png 1986w\" sizes=\"(max-width: 226px) 100vw, 226px\" \/><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}},\"textColor\":\"black\"} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><span style=\"color: #666699;\">2020<\/span><\/strong><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/doi.org\/10.1039\/D0SC03713C\" target=\"_blank\" rel=\"noreferrer noopener\">Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions, and molecular orbital control<\/a><\/strong><a href=\"http:\/\/Catalysis by the JmjC histone demethylase KDM4A integrates substrate dynamics, correlated motions and molecular orbital control\" target=\"_blank\" rel=\"noreferrer noopener\">,<\/a> Rajeev Ramanan, Shobhit S. Chaturvedi, Nicolai Lehnert, Christopher J. Schofield, Tatyana G. Karabencheva-Christova and Christo Z. Christov, <strong>Chemical Science<\/strong>,\u00a011, 9950 \u2013 9961.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/doi.org\/10.1021\/acscentsci.0c00312\" target=\"_blank\" rel=\"noreferrer noopener\">Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair<\/a><\/strong>, Sodiq O. Waheed, Shobhit S. Chaturvedi, Nicolai Lehnert, Christopher J. Schofield, Christo Z. Christov and\u00a0Tatyana G. Karabencheva-Christova, <strong>ACS Central Science<\/strong>, 6, 5, 795\u2013814. Featured on the supplementary cover.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-486 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-226x300.jpg\" alt=\"\" width=\"183\" height=\"243\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-226x300.jpg 226w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-770x1024.jpg 770w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-768x1021.jpg 768w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-1155x1536.jpg 1155w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-1540x2048.jpg 1540w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1-203x270.jpg 203w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/02\/ACS-Central-Science-2-1.jpg 1717w\" sizes=\"(max-width: 183px) 100vw, 183px\" \/><\/h6>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/doi.org\/10.1021\/acscatal.9b04907\" target=\"_blank\" rel=\"noreferrer noopener\">Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation<\/a><\/strong><a href=\"http:\/\/Catalysis by the Non-Heme Iron(II) Histone Demethylase PHF8 Involves Iron Center Rearrangement and Conformational Modulation of Substrate Orientation\" target=\"_blank\" rel=\"noreferrer noopener\">,<\/a> Shobhit S. Chaturvedi,\u00a0Rajeev Ramanan,\u00a0Nicolai Lehnert,\u00a0Christopher J. Schofield,\u00a0Tatyana G. Karabencheva-Christova and\u00a0Christo Z. Christov, <strong>ACS Catalysis<\/strong>, 10, 1195-1209.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:image {\"align\":\"right\",\"id\":486,\"width\":220,\"height\":292,\"sizeSlug\":\"medium\"} --><\/h6>\n<h6><!-- \/wp:image --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2019<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30817054\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational Dynamics Underlies Different Functions of Human KDM7 Histone Demethylases<\/strong><\/a>, Shobhit S. Chaturvedi, Rajeev Ramanan, Sodiq O. Waheed, Jon Ainsley, Martin Evison, Jennifer M. Ames, Christopher J. Schofield, Tatyana G. Karabencheva-Christova and Christo Z. Christov, <strong>Chemistry-A European Journal, <\/strong>25, 5422-5426.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30720838\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational flexibility influences structure-function relationships in nucleic acid N-methyl demethylases<\/strong><\/a><strong>, <\/strong>Sodiq O. Waheed, Rajeev Ramanan, Shobhit S. Chaturvedi, Jon Ainsley, Martin Evison, Jennifer M. Ames, Christopher J. Schofield, Christo Z. Christov and Tatyana G. Karabencheva-Christova, <strong>Organic &amp; Biomolecular Chemistry, <\/strong>17, 2223-2231.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2018<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30113044\/\" target=\"_blank\" rel=\"noreferrer noopener\">Integrating Molecular Probes and Molecular Dynamics to Reveal Binding Modes of GLUT5 Activatory and Inhibitory Ligands<\/a>,<\/strong> Jon Ainsley, Shobhit S. Chaturvedi, Tatyana G. Karabencheva-Christova, Marina Tanasova, and\u00a0Christo Z. Christov, <strong>Chemical Communications, <\/strong>54, 9917-9920<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.8b00385\" target=\"_blank\" rel=\"noreferrer noopener\">Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase<\/a>, <\/strong>Jon Ainsley,\u00a0Adrian J. Mulholland,\u00a0Gary W. Black,\u00a0Olivier Sparagano,\u00a0Christo Z. Christov, and\u00a0Tatyana G. Karabencheva-Christova, <strong>ACS Omega\u00a0<\/strong>3,\u00a05,\u00a04847-4859.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29161042\/\" target=\"_blank\" rel=\"noreferrer noopener\">Conformational Dynamics of Matrix Metalloproteinase-1\u2022Triple-helical Peptide Complexes<\/a>, <\/strong>Tatyana G. Karabencheva-Christova, Christo Z. Christov, Gregg B. Fields, <strong>Journal of Physical Chemistry B<\/strong>.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2017<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/www.nature.com\/articles\/s41598-017-17789-x\" target=\"_blank\" rel=\"noreferrer noopener\">Mechanistic Insights into the Reaction of Chlorination of Tryptophan Catalyzed by Tryptophan 7-Halogenase<\/a>, <\/strong>Tatyana G. Karabencheva-Christova, Juan Torras, Alessio Lodola, Adrian J. Mulholland, Christo Z. Christov,<strong> Scientific Reports <\/strong>7, 17395.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1039\/C7TB02583A\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Fluorescent Probes for Sensitive and Selective Detection of pH Changes in Live Cells in Visible and Near-infrared Channels<\/strong><\/a>, Mingxi Fang,\u00a0Rashmi Adhikari,\u00a0Jianheng Bi,\u00a0Wafa Mazi,\u00a0Nethaniah Dorh,\u00a0Jianbo Wang,\u00a0Nathan Conner,\u00a0Jon Ainsley,\u00a0Tatyana G. Karabencheva-Christova,\u00a0Fen-Tair Luo\u00a0and\u00a0Ashutosh Tiwari, <strong>Journal of Material Chemistry B<\/strong>, 5, 9579-9590.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28894966\/\" target=\"_blank\" rel=\"noreferrer noopener\">Targeting cancer-specific glycans by cyclic peptide lectinomimics<\/a><\/strong>, Maria C. Rodriguez, Austin B. Yongye, Mihael Cudic, Karina Martinez-Mayorga, Enbo Liu, Barbara M. Mueller, Jon Ainsley, Tatyana Karabencheva-Christova, Christo Z. Christov, Mare Cudic, Predrag Cudic, <strong>Amino Acids<\/strong>, (2017).<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2016<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5085758\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1<\/strong><\/a>, Warispreet Singh, Gregg B. Fields, Christo Z. Christov, Tatyana G. Karabencheva-Christova, <strong>International Journal of Molecular Sciences<\/strong>, 17, 1727.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4792301\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Importance of Linker Region in Matrix Metalloproteinase-1 Domain Interactions<\/strong><\/a>, Warispreet Singh, Gregg B. Fields, Christo Z. Christov, Tatyana G. Karabencheva-Christova, <strong>RSC Advances<\/strong>, 6, 23223-23232.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1039\/C6RA01899H\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dimerization and Ligand Binding in TyrosylProtein Sulfotransferase &#8211; 2 are influenced by Molecular Motions<\/strong><\/a>, Warispreet Singh, Tatyana G. Karabencheva-Christova, Olivier Sparagano, Gary W. Black, Petar Y. Petrov, and Christo Z. Christov, <strong>RSC Advances,<\/strong>\u00a06, 18542-18548.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1039\/C5RA25365A\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational Flexibility influences Structure-Function Relationships in TyrosylProtein Sulfotransferase<\/strong><\/a>, Warispreet Singh, Tatyana G. Karabencheva-Christova, Olivier Sparagano, Gary W. Black and Christo Z. Christov, <strong>RSC Advances<\/strong>,\u00a06, 11344 \u2013 113526.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2015<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/www.nature.com\/articles\/srep20107\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational Dynamics, Ligand Binding, and Effects of Mutations in NirE S-Adenosyl-L-Methionine-Dependent Uroporphyrinogen III Methyltransferase<\/strong><\/a>, Warispreet Singh, Tatyana G. Karabencheva-Christova, Gary W. Black, Jon Ainsley, Lynn Dover, and Christo Z. Christov, <strong>Nature Scientific Reports<\/strong>.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2014<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24675991\/\" target=\"_blank\" rel=\"noreferrer noopener\">How Does Conformational Flexibility Influence Key Structural Features Involved in Activation of Anaplastic Lymphoma Kinase?<\/a><\/strong> T. Karabencheva, Christian C. Lee, Rossen Donev, Gary W. Black, and Christo Z. Christov, <strong>Molecular Biosystems (RSC)<\/strong>, 10, 1490-1495.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.5560\/zna.2014-0021\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Computational Study of the Structure, the Flexibility, and the Electronic Circular Dichroism of Staurosporine &#8211; a Powerful Protein Kinase Inhibitor<\/strong><\/a>, Tatyana G. Karabencheva-Christova, Warispreet Singh and Christo Z. Christov, <strong>Zeitschrift fur Naturforschung A<\/strong>, 69a,\u00a0331\u2009\u2013\u2009338.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2013<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"http:\/\/10.1016\/j.bpj.2013.01.040\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational Effects on the pro-(S) Hydrogen Abstraction Reaction in Cyclooxygenase-1: An Integrated QM\/MM and MD Study<\/strong><\/a>, C. Christov, Alessio Lodola, Tatyana G. Karabencheva-Christova, Shunzhou Wang, Peter V. Coveney, and Adrian J. Mulholland, <strong>Biophysical Journal<\/strong>, 104, L5-L7.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0056874\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Conformational Effects on the Circular Dichroism of Human Carbonic Anhydrase II: A Multilevel Computational Study<\/strong><\/a>, T. Karabencheva-Christova, Uno Carlsson, Kia Balali-Mood, Gary W. Black and Christo Z. Christov, <strong>PLoS ONE<\/strong>, 8, e67874.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2011<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21132834\/\" target=\"_blank\" rel=\"noreferrer noopener\">Integrated Synthetic, Pharmacological and Computational Investigation of cis\u20112\u2011(3,5\u2011dichlorophenylcarbamoyl) cyclohexane carboxylic acid enantiomers as Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 4<\/a><\/strong>, Christo Z. Christov, Patricia Gonz\u00e1lez-Bulnes, Fanny Malhaire, Tatyana G. Karabencheva, Cyril Goudet, Jean-Philippe Pin, Amadeu Llebaria and Jesus Giraldo, <strong>ChemMedChem<\/strong>, 6, 1, 131-140.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2010<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1016\/j.bpc.2010.05.003\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Individual Contributions of the Aromatic Chromophores to the Near-UV Circular Dichroism in Class A \u03b2-lactamases: A Comparative Computational Analysis<\/strong><\/a>, Tatyana G. Karabencheva, Rossen Donev, Kia Balali-Mood, and Christo Z. Christov, <strong>Biophysical Chemistry<\/strong>, 151 (1-2): 39-45.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00214-010-0744-4\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Computational Insight in Protein Circular Dichroism: Detailed Analysis of Contributions of Individual Chromophores in TEM-1 \u00df-Lactamase<\/strong><\/a>, Christo Z. Christov, and Tatyana G. Karabencheva, <strong>Theoretical Chemistry Accounts<\/strong>, 128, 25-37.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2008<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0009261408003461?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Aromatic Interactions and Rotational Strengths within Protein Environment Effects: An Electronic Structural Study on \u03b2-Lactamases from Class A<\/a><\/strong>, Christo Z. Christov, Tatyana G. Karabencheva-Christova, and Alessio Lodola, <strong>Chemical Physics Letters,<\/strong> 456, 89-95 (2008).<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/doi.org\/10.1016\/j.compbiolchem.2008.02.003\" target=\"_blank\" rel=\"noreferrer noopener\">Relationship between<\/a> <a href=\"https:\/\/doi.org\/10.1016\/j.compbiolchem.2008.02.003\" target=\"_blank\" rel=\"noreferrer noopener\">Chiroptical Properties, Structural Changes, and Interactions in Enzymes: A computational Study on \u03b2-lactamases from Class A<\/a><\/strong>, Christo Z. Christov, Tatyana G. Karabencheva, and Alessio Lodola, <strong>Computational Biology and Chemistry<\/strong>, 32, 167-175.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><span style=\"color: #666699;\"><strong>2004<\/strong><\/span><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1016\/j.cplett.2004.08.035\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Mechanisms of Generation of Rotational Strengths in TEM-1 \u03b2-lactamase. Part I: Theoretical Analysis of the Influence of Conformational Changes in the Near-UV<\/strong><\/a>, Christo Z. Christov, and Tatyana G. Karabencheva, <strong>Chemical Physics Letters<\/strong>, 396, 282-287.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1016\/j.cplett.2004.11.008\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Mechanisms of Generation of Rotational Strengths in TEM-1 \u03b2-lactamase. Part II: Theoretical Study of the Effects of the Electrostatic Interactions in the Near-UV<\/strong><\/a>, Christo Z. Christov, Alexander Kantardjev, Tatyana G. Karabencheva, and Frederic Tielens, <strong>Chemical Physics Letters<\/strong>, 400,\u00a0524-530.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-494 alignright\" src=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/03\/9780128118771_cover-200x300.jpg\" alt=\"\" width=\"200\" height=\"300\" srcset=\"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/03\/9780128118771_cover-200x300.jpg 200w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/03\/9780128118771_cover-180x270.jpg 180w, http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-content\/uploads\/2021\/03\/9780128118771_cover.jpg 527w\" sizes=\"(max-width: 200px) 100vw, 200px\" \/><\/h6>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/doi.org\/10.1016\/j.cplett.2004.09.099\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Comparative Theoretical Study of the Mechanisms of Generation of Rotational Strengths in the Near-UV in \u03b2-Lactamases from class A<\/strong><\/a>, Tatyana G. Karabencheva, and Christo Z. Christov, <strong>Chemical Physics Letters<\/strong>, 398, 511-516.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- \/wp:list --><\/h6>\n<h6><!-- wp:paragraph --><\/h6>\n<h6><!-- \/wp:paragraph --><\/h6>\n<h6><!-- wp:group --><\/h6>\n<div>\n<h6><!-- wp:group --><\/h6>\n<p><!-- wp:image {\"align\":\"right\",\"id\":494,\"width\":220,\"height\":311,\"sizeSlug\":\"large\"} --><\/p>\n<figure><\/figure>\n<p><!-- \/wp:image --><\/p>\n<h6><!-- \/wp:group --><\/h6>\n<h6><!-- wp:list {\"style\":{\"typography\":{\"fontSize\":17}}} --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\"><!-- wp:list-item --><\/ul>\n<\/li>\n<\/ul>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong>Book chapters<\/strong><\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/www.elsevier.com\/books\/non-heme-iron-enzymes-structures-and-mechanisms\/karabencheva-christova\/978-0-12-818773-9\" target=\"_blank\" rel=\"noreferrer noopener\">Non-heme Iron Enzymes: Structures and Mechanisms<\/a><\/strong>, Shobhit S. Chaturvedi, Rajeev Ramanan, Sodiq O. Waheed, Tatyana G. Karabencheva-Christova, and Christo Z. Christov, Structure-function relationships in KDM7 histone demethylases, Volume 117, <strong>Advances in Protein Chemistry and Structural Biology<\/strong>, 113-125, (2019).<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1876162318300464\">Combined Quantum Mechanics and Molecular Mechanics Studies of Enzymatic Reaction Mechanisms<\/a><\/strong>, Jon Ainsley, Alessio Lodola, Adrian J. Mulholland, Christo Z. Christov, and Tatyana G. Karabencheva-Christova, <strong>Advances in Protein Chemistry and Structural Biology<\/strong>, 113, 1-32, <strong>(2018)<\/strong>.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1876162317300226\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Collagenolytic Matrix Metalloproteinase Structure-Function Relationships: Insights From Molecular Dynamics Studies<\/strong><\/a>, Tatyana G. Karabencheva-Christova, Christo Z. Christov,\u00a0Gregg B. Fields, <strong>Advances in Protein Chemistry and Structural Biology<\/strong>. 109, 1-24, <strong>(2017)<\/strong>. Featured on the front cover.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h6><!-- \/wp:list-item --><\/h6>\n<h6><!-- wp:list-item --><\/h6>\n<ul style=\"font-size: 17px;\">\n<li style=\"list-style-type: none;\">\n<ul style=\"font-size: 17px;\">\n<li>\n<h6><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780123812643000035\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling<\/strong><\/a>, Tatyana G. Karabencheva, and Christo Z. Christov, <strong>Advances in Protein Chemistry and Structural Biology<\/strong>, 80, 85-115, <strong>(2010)<\/strong>.<\/h6>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><!-- \/wp:list-item --><\/p>\n<p><!-- \/wp:list --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<\/div>\n<p><!-- \/wp:group --><\/p>\n<p><!-- wp:paragraph --><\/p>\n<p><!-- \/wp:paragraph --><\/p>\n<p><!-- wp:image --><\/p>\n<figure><img alt=\"\" \/><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:image --><\/p>\n<figure><img alt=\"\" \/><\/figure>\n<p><!-- \/wp:image --><\/p>\n<p><!-- wp:image --><\/p>\n<figure><img alt=\"\" \/><\/figure>\n<p><!-- \/wp:image --><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d09d3d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d09d3d7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0cae4d6\" data-id=\"0cae4d6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e15c12a elementor-widget elementor-widget-text-editor\" data-id=\"e15c12a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u00a0 2025 Regio- and Stereoselective Halogenation by an Iron(II)- and 2-Oxoglutarate-Dependent Halogenase in the Biosynthesis of Halogenated Nucleosides, Philip M. Palacios, Xiaoyun Li, Simahudeen Bathir Jaber Sathik Rifayee, Haoyu Tang, Tatyana Karabencheva-Christova, Christo Christov, Wei-chen Chang and Yisong Guo, Journal of the American Chemical Society. Revealing the catalytic mechanism of the Fe(II)\/2-oxoglutarate-dependent human epigenetic modifying [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_eb_attr":"","footnotes":""},"class_list":["post-120","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/pages\/120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/comments?post=120"}],"version-history":[{"count":228,"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/pages\/120\/revisions"}],"predecessor-version":[{"id":2244,"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/pages\/120\/revisions\/2244"}],"wp:attachment":[{"href":"http:\/\/chem.sites.mtu.edu\/karabencheva-christova\/wp-json\/wp\/v2\/media?parent=120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}